Every summer the Croucher Foundation funds short courses that aim to educate and inspire postgraduate students and early career researchers from Hong Kong an...
Precision Genome Engineering by CRISPR: Applications in Biology and Medicine
genome engineering by CRISPR is game-changing. The use of CRISPR to knockout or
knockin genes precisely has increased explosively in biomedical research and as
novel therapeutics. CRISPR-mediated knockout of target genes has become the
standard for loss-of-function studies in mammalian cells and animals.
CRISPR-based forward genetic screens and other applications of CRISPR including
those in live cell imaging, disease modelling and treatment have brought
revolutionary thoughts and enabling tools to various fields across biology and
medicine. The CRISPR revolution is not only in the lab, but will also be in the
clinic. However, there is a big gap between the rapid development of CRISPR and
its potential applications in the local and the wider region, where it is still
much underused. The goal of our course is to fill this gap by educating our
young scientists with cutting-edge technologies, providing a forum and platform
for discussion and knowledge exchange, promoting wider use of CRISPR, and
strengthening our link to the world. Our course will not only introduce
state-of-the-art developments but also provide hands-on training. In short, it
is hoped that the small, but dedicated group of young scientists trained will
bring a critical change to our region. We will provide our participants with both
state-of-the-art knowledge about CRISPR and hands-on training of a CRISPR
experiment. The course will be multidisciplinary covering genetics, cancer
biology, stem cell biology, virology and animal models. We will strike a
balance between general introduction of CRISPR and discussion of emerging
technologies such as CRISPR screens. The practical section will include a
typical CRISPR knockout experiment. We aspire to develop our course into a
flagship course on CRISPR in Asia.
Precision genome engineering by CRISPR is a game-changing technology that holds the promise to revolutionize modern biology and medicine. This is the first course or forum in Asia devoted specifically to CRISPR and we have four specific aims: 1) To bring together a group of local and regional researchers interested in CRISPR and educate them with innovative thoughts and cutting-edge technologies; 2) To provide a forum for discussion and knowledge exchange, facilitating a better understanding of the breath and complexity of CRISPR technology among participants and the wider research community; 3) To promote the use of CRISPR technology in Hong Kong and the wider region; 4) To foster collaborations and to strengthen the link of the local and the wider research community to the world.