Programme
Programme
Day 1
Foundation of Retrotransposon Regulation
The Hong Kong University of Science and Technology
Clear Water Bay Campus
Padma and Hari Harilela Lecture Theater (LT-C)
09:30 — 10:00
Registration & Coffee
10:00 — 10:15
Welcome Address & Course Overview
10:15 — 11:15
Session 1: Molecular Control of Retrotransposons
Keynote Lecture
Didier Trono Professor, Laboratory of Virology and Genetics, Ecole Polytechnique Federale de Lausanne
11:15 — 11:30
Trainee Talk
Yizhi Yan PhD Candidate, Institute for the Advanced Study of Human Biology, Kyoto University
“Computational Prediction of Interactions Between TE-Derived Enhancers and Genes”
11:30 — 12:00
Short Talk
Andrew Hutchins Associate Professor, Department of Systems Biology, Southern University of Science and Technology
“Transposable Elements in normal transcripts and as determinants of 3D genome structure”
12:00 — 13:30
Lunch Break
13:30 — 14:30
Session 2: Germline Safeguards: Retrotransposon Silencing in Development
Keynote Lecture
Matthew Lorincz Professor, Department of Medical Genetics, University of British Columbia
“How retroelements shape the epigenome and transcriptome: lessons from the germline and early embryo”
14:30 — 14:45
Trainee Talk
Xiangyu Ouyang PhD Student, School of Biomedical Sciences, University of Hong Kong
“METTL3-dependent m6A RNA methylation regulates transposable elements and represses human naive pluripotency through transposable element-derived enhancers”
14:45 — 15:15
Short Talk
Danny Leung Associate Professor, Division of Life Science, The Hong Kong University of Science and Technology
"Unveiling The Role Of Retrotransposons In Placental Development And Disease"
15:15 — 15:30
Coffee Break
15:30 — 17:30
Poster and Networking Session
Day 2
Retrotransposons in Disease and Therapy
The Hong Kong University of Science and Technology
Clear Water Bay Campus
Padma and Hari Harilela Lecture Theater (LT-C)
09:30 — 10:00
Morning Coffee & Networking
10:00 — 11:00
Session 3: Epigenetic Barriers to Retrotransposon Activation
Keynote Lecture
Yoichi Shinkai Chief Scientist, Cellular Memory Laboratory, RIKEN
“Has the nature of DNA and histone methylation as a repressive epigenome of retrotransposons been clarified?”
11:00 — 11:15
Trainee Talk
Qinghong Jiang PhD candidate, Division of Life Science, The Hong Kong University of Science and Technology
“Dissecting the Regulatory Role of Retrotransposons in Response to Interferon-gamma”
11:15 — 11:45
Short Talk
Yuka Iwasaki Team Director, Center for Integrative Medical Sciences, RIKEN
“Epigenetic Regulation of Transposons in Germline and Somatic Cells”
11:45 — 13:30
Lunch break
13:30 — 14:30
Session 4: Transposable Elements in Tumorigenesis
Keynote Lecture
Ting Wang Head of Department of Genetics, Washington University in St. Louis
14:30 — 14:45
Trainee Talk
Cheuk Yin Cheng PhD student, Division of Life Science, The Hong Kong University of Science and Technology
“Global DNA hypomethylation drives cryptic activation of retrotransposons-driven transcripts with prognostic and immunotherapeutic implications in hepatocellular carcinoma”
14:45 — 15:15
Coffee Break
15:15 — 16:15
Session 5: Therapeutic and Diagnostic Potential of Retrotransposons
Keynote Lecture
Katherine Chiappinelli Associate Professor, Department of Microbiology, Immunology and Tropical Medicine, George Washington University
“The Viral Mimicry Response to Transposable Elements in Cancer”
16:15 — 16:30
Trainee Talk
Jayne Barbour Postdoctoral Fellow, The Centre for Oncology and Immunology, InnoHK
“ADAR Prevents the DNA Damage Response from Initiating dsRNA Mediated Interferon Activation”
16:30 — 17:00
Short Talk
Jian Yan Associate Professor, Department of Biomedical Sciences, City University of Hong Kong
“HERV-H RNA Forming Non-canonical Triplex Structure with rDNA Clusters Governs Ribosome Biogenesis”
18:30 — 20:30
Banquet
Day 3
Retrotransposons Across Genomes and Development
The Hong Kong University of Science and Technology
Clear Water Bay Campus
Padma and Hari Harilela Lecture Theater (LT-C)
09:30 — 10:00
Morning Coffee & Networking
10:00 — 11:00
Session 6: Comparative and Evolutionary Perspectives on Retrotransposons
Keynote Lecture
Guillaume Bourque Professor, Department of Human Genetics, McGill University
“New tools to understand the roles of transposable elements in the human genome”
11:00 — 11:15
Trainee Talk
Ziqiang Zhou PhD student, School of Life Sciences, Tsinghua University
“Composite Transposons with bivalent histone mark function as RNA-dependent enhancers in cell fate regulation”
11:15 — 11:45
Short Talk
Jason Wong Professor, School of Biomedical Sciences, University of Hong Kong
“Examining the regulation and function of human endogenous retrovirus transcripts in cancer”
11:45 — 13:30
Lunch break
13:30 — 14:30
Session 7: Retrotransposons in Embryogenesis and Early Lineages
Keynote Lecture
Nian Liu Associate Professor, School of Life Sciences and Center for Life Sciences, Tsinghua University
“Regulation and function of human retrotransposons”
14:30 — 14:45
Trainee Talk
Martin Wong PhD Candidate, Medical Genetics, Life Sciences Institute, University of British Columbia
"Role of KMT2B in Safeguarding CpG Island Promoters from Transposable Element-Mediated DNAme Gain in Early Mouse Development"
14:45 — 15:45
Panel Discussion: Collaborative Horizons in Retrotransposon Research
15:45 — 16:00
Closing Session: Key Takeaways & Future Perspectives
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