Chayasith received his A.B. degree in chemistry from Harvard, during which he worked in the laboratory of Professor Gregory Verdine on the design and synthesis of mechanism-based inhibitors of DNA repair enzymes. He then obtained his PhD in biological chemistry from MIT under the mentorship of Alice Ting. As a PhD student, Chayasith developed several chemical biology tools, including the first fluorophore ligase for protein labelling in cells, the fastest variant of biocompatible metal-catalysed click chemistry, and a general route for chemical masking of sulfonated compounds for cellular delivery. After completing his PhD, Chayasith won a Marie Curie Postdoctoral fellowship and joined Professor Jason Chin’s laboratory at MRC Laboratory of Molecular Biology, Cambridge. There, Chayasith developed genetic code expansion as a tool for live-cell and super-resolution imaging of cellular proteins, as well as an engineered stapled ribosome, which enables directed evolution of new ribosome function. Chayasith was also a college research associate at St John’s College, Cambridge, where he took part in supervision of Natural Sciences undergraduate students. Chayasith joined the BSE division of VISTEC in Thailand in 2018 as a lecturer.