CAS-Croucher Joint Laboratories

The CAS-Croucher Funding Scheme for Joint Laboratories is the outcome of an agreement between The Chinese Academy of Sciences (CAS) and the Croucher Foundati...

Induced Pluripotent Stem Cell (iPSC)-Based Platform for treating hyperlipidemia

This joint laboratory will discover potentially pathways for modulation of LDL levels in blood and the management of hyperlipidemia.

Professor Hung-fat Tse, Department of Medicine, The University of Hong Kong

Hyperlipidemia is a group of conditions that present as abnormally elevated lip levels in blood and affect approximately 20-30% of the population. It is a critical risk factor for a host of diseases including the development of various cardiovascular diseases, type II diabetes and hypertension. A percentage of all cases of hyperlipidemia are familial and mutations in the LDL receptor (LDLR), ApoB, and other known loci account for a significant number of these patients, but many others have an unknown cause. Statins (HMG-CoA reductase inhibitors) have been widely used in the treatment of patients with hyperlipidemia. These drugs work by directly inhibition cholesterol biosynthesis in the liver, but also indirectly increase LDL update through up-regulation of LDLR. A problem of statins is that they don’t work in all patients and have relevant secondary effects. PCSK9 antibody therapy is an alternative solution. however its long term safety and efficacy of PCSK9 antibody therapy is still under investigation, and its high cost makes it difficult for normal patients to afford.

The group propose method to discover potentially pathways for modulation of LDL levels in blood and the management of hyperlipidemia.

A Joint Laboratory in partnership with the Chinese Academy of Sciences.

Stay in the loop!

Subscribe to keep up with the latest from Croucher Foundation.

Passionate about science?
Stay updated with the latest scientific developments in Hong Kong through Croucher News.

Subscribe to our regular newsletter and receive a digest of key science stories straight to your inbox. You'll also get updates from the Croucher Foundation on scholarships, scientific exchanges, and more.

Subscribe now and stay informed about Hong Kong's dynamic scientific landscape.


First name

Last name