Asymmetric catalysis developments
Targeted osteosarcoma therapy with aptamer-conjugated triptolide to boost efficacy and minimize side effects.
The project focused on chirality, asymmetric catalysis, carbon-hydrogen bond activation, environmental-friendly catalysis, polymer sciences, and total synthesis of bioactive molecules. The laboratory aimed to develop new SIOCPhox ligands and tetrahydroxytetraphenylene catalysts for asymmetric carbon-carbon bond formation. Benzylic substituted chiral oxazoline ligands and palladium complexes for asymmetric allylic alkylation Heck reactions were performed in this project. The team explored these catalysts' properties and applied new C-C bond formation reactions to synthesise dhilirolide D and the isocedrene family. These enhanced understanding in catalyst design, and development of new catalyst systems for green chemistry, provided insights into reaction mechanisms and structure-activity relationships.
Key topics
- Asymmetric catalysis
- Carbon-carbon bond formation
- SIOCPhox ligands
- Tetrahydroxytetraphenylene catalysts
Other projects
Stay in the loop!
Subscribe to keep up with the latest from Croucher Foundation.