Asymmetric catalysis developments
Targeted osteosarcoma therapy with aptamer-conjugated triptolide to boost efficacy and minimize side effects.
The project focused on chirality, asymmetric catalysis, carbon-hydrogen bond activation, environmental-friendly catalysis, polymer sciences, and total synthesis of bioactive molecules. The laboratory aimed to develop new SIOCPhox ligands and tetrahydroxytetraphenylene catalysts for asymmetric carbon-carbon bond formation. Benzylic substituted chiral oxazoline ligands and palladium complexes for asymmetric allylic alkylation Heck reactions were performed in this project. The team explored these catalysts' properties and applied new C-C bond formation reactions to synthesise dhilirolide D and the isocedrene family. These enhanced understanding in catalyst design, and development of new catalyst systems for green chemistry, provided insights into reaction mechanisms and structure-activity relationships.
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Original project funded for three years from 2012
Key topics
- Asymmetric catalysis
- Carbon-carbon bond formation
- SIOCPhox ligands
- Tetrahydroxytetraphenylene catalysts
Directors
Henry Wong
Emeritus Professor, Research Professor at the Chinese University of Hong Kong
Xuelong Hou
Professor at the CAS Institute of Organic Chemistry, Shanghai
Other projects
Adult stem cell regeneration
Original project funded for three years from 2024
Chiral electronic materials
Original project funded for three years from 2024
Glioma drug resistance
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Treg heart regeneration
Original project funded for three years from 2024
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