George Xu is a distinguished figure in dermatopathology at the Perelman School of Medicine, University of Pennsylvania. Specialising in melanoma research and clinical practice, Xu focuses on the molecular mechanisms behind melanoma progression, therapeutic resistance, and the tumour microenvironment. His research employs cutting-edge techniques like high-throughput sequencing, single-cell analysis, and advanced imaging to investigate genetic alterations driving melanoma metastasis and resistance to immunotherapy. Xu's lab also contributes to skin cancer biomarker discovery, aiding early detection and personalised treatment strategies. Beyond research, he plays a key role in clinical pathology, specialising in complex skin cancers and mentoring the next generation of medical professionals. His numerous publications in peer-reviewed journals and collaborative approach advance both dermatopathology and oncology, leaving a significant impact on the medical community.