Duo Zhang is a special associate professor at the School of Pharmacy, Shenzhen Technology University, and an associate researcher at the Cancer Immunology Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences. He earned his PhD in Tumor Biology from the Perelman School of Medicine at the University of Pennsylvania. His research focuses on understanding the tumor microenvironment and the mechanisms of resistance to immunotherapy, particularly CAR-T cell therapy. Duo is especially interested in how endothelial cell metabolism and vascular remodeling influence immune cell infiltration in solid tumors. In recent years, his group has developed tools such as endothelial-targeted lipid nanoparticles and in vivo CAR-T tracing systems to explore these mechanisms more effectively. He hopes that their work will contribute to improving the effectiveness of immunotherapy for challenging tumors like glioblastoma.