My research interest is targeting to use custom multi-model microscopy combining oblique plane microscopy (OPM) and oblique back-illumination microscopy (OBM) for zebrafish in-vivo leukaemia analysis. Zebrafish is a well-developed animal model for leukaemia, but the current research requires to kill the zebrafish for their leukaemia status investigations. This hinders the capability in working on long-term drug responses for leukaemia. Therefore, we design to use OPM and OBM to provide both fluorescent and label-free images of the zebrafish peripheral flowing blood cells, aiming to work on in-vivo leukaemia zebrafish analysis. Given that there are no effective fluorescent labels on zebrafish leukaemia cells, we are currently developing a software system in tracking and extracting features of the flowing blood cells through the label-free images.