Leon Shi is a research associate at the Department of Medicine and Therapeutics, the Chinese University of Hong Kong. Trained as a bioinformaticist, he is interested in leveraging cutting-edge computational approaches, large-scale omics data, and population cohorts to elucidate the genetic architecture of complex diseases including cancers and diabetes. His current research focuses on the genetics of diabetic complications, with particular emphasis on diabetic kidney disease (DKD) in East Asian populations. His work aims to deepen understanding of the disease etiology while unraveling population-specific risk factors and potential therapeutic targets, ultimately contributing to precision medicine approaches in diabetes care. His methodological expertise includes genome-wide association analysis, polygenic risk scoring, machine-learning modeling, and multi-omic data integration—techniques he employs to address critical questions in complex disease genetics.