Key topics
When these organs are exposed to metabolic stress, inflammatory response is stimulated in both parachymal and immune cells. This kind of metabolic stress-induced inflammation or immune response plays an important role in the pathophysiology of many chronic diseases including metabolic syndrome, cardiovascular diseases, cancer, autoimmune diseases, and respiratory dysfunction. The climbing prevalence of obesity, incidents of nutritional imbalance, and consumption of processed food all contribute to the augmented metabolic inflammation, thus increasing the risk of developing these chronic diseases. The aforementioned inflammation associated chronic diseases compose of more than 80% of noncommunicable diseases, which account for ~90% of the total medical cost in senior population worldwide. The emerging study of immunometabolism advances the therapeutic strategies of treating these often multiple-coexisting chronic diseases.
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