Tsachy Wiessman graduated summa cum laude with a B.Sc. in Electrical Engineering from the Technion in 1997, and later earned a PhD from the same institution in 2001. He worked at Hewlett-Packard Laboratories with the Information Theory Group until 2003, and has been a professor of Electrical Engineering at Stanford University since 2003. He spent the academic years 2007-2009 on leave with the Department of Electrical Engineering at the Technion.

His research focuses on Information Theory and Communications, Statistical Signal Processing, the interplay between them, and their applications. He is the inventor of several patents and involved in a number of companies as researcher or member of the technical board. His honors include an NSF CAREER award, several best paper awards, Horev fellowship for Leaders in Science and Technology, Henry Taub prize for excellence in research, incumbent of the STMicroelectronics Chair in the School of Engineering. He is an IEEE fellow. He is also on the editorial boards of the IEEE Transactions on Information Theory and Foundations and Trends in Communications and Information Theory, and is a founding Director of the Stanford Compression Forum.