Editor-in-Chief, eLife Principle Investigator, Howard Hughes Medical Institute Member of National Academy of Sciences of USA Professor Department of Molecular & Cell Biology, University of California at Berkeley, USA Expertise: Protein Sorting and Disease Connections in the Secretory Pathway of Yeast and Mammalian Cells Research interests: 1) Organelle assembly, 2) Intracellular protein transport, 3) Assembly of cellular organelles, 4) Alzheimer's Disease Publications:  COPII-coated membranes function as transport carriers of intracellular procollagen I. Gorur A, Yuan L, Kenny SJ, Baba S, Xu K, Schekman R. J Cell Biol. 2017 Apr 20. pii: jcb.201702135. doi: 10.1083/jcb.201702135.  Remodeling of ER-exit sites initiates a membrane supply pathway for autophagosome biogenesis. Ge L, Zhang M, Kenny SJ, Liu D, Maeda M, Saito K, Mathur A, Xu K, Schekman R. EMBO Rep. 2017 Jul 28. pii: e201744559. doi: 10.15252/embr.201744559.  Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment. Sirkis DW, Aparicio RE, Schekman R. Mol Biol Cell. 2017 Aug 2. pii: mbc.E17-06-0423. doi: 10.1091/mbc.E17-06-0423.  TFG facilitates outer coat disassembly on COPII transport carriers to promote tethering and fusion with ER-Golgi intermediate compartments. Hanna MG 4th, Block S, Frankel EB, Hou F, Johnson A, Yuan L, Knight G, Moresco JJ, Yates JR 3rd, Ashton R, Schekman R, Tong Y, Audhya A. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7707-E7716. doi: 10.1073/pnas.1709120114. Epub 2017 Aug 29.  Broad role for YBX1 in defining the small noncoding RNA composition of exosomes. Shurtleff MJ, Yao J, Qin Y, Nottingham RM, Temoche-Diaz MM, Schekman R, Lambowitz AM. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995. doi: 10.1073/pnas.1712108114. Epub 2017 Oct 10.