Jonas Ries is a professor for Advanced Microscopy and Cellular Dynamics at the University of Vienna. He obtained his PhD in Biophysics from the Dresden University of Technology and conducted postdoctoral research at the ETH Zurich, focusing on the development of advanced imaging techniques. His research aims to push the boundaries of optical microscopy to visualise molecular processes at nanometer resolution within living cells. Ries’ group develop optical super-resolution microscopy technologies that will allow them to visualise the structure and the dynamics of molecular machines in living cells on the nanoscale. His interdisciplinary team of physicists, biologists, computer scientists and engineers are developing new approaches for single-molecule localisation microscopy (SMLM) to measure the precise 3D locations of proteins at high throughput and the new MINFLUX technology to probe conformational changes of protein machines in the living cell with nanometer spatial and millisecond temporal resolution. They use these methods to gain mechanistic insights into endocytosis and other cellular protein machines.