Time-lapse imaging systems for embryo incubation in IVF
The Chinese University of Hong Kong and Queen Mary University of London have led a significant international study on time-lapse imaging (TLI) systems used in embryo incubation during in vitro fertilisation (IVF). Despite the advanced monitoring capabilities of TLI systems, the study found no clinical advantage over conventional methods. This research, the largest international study of its kind, involved 1,500 participants in Hong Kong and the UK.
The study was conducted between June 2018 and September 2022 and was recently published in The Lancet, with Dr Priya Bhide from Queen Mary University and Dr David Chan from the Chinese University of Hong Kong as the lead co-authors. The researchers conducted a multicentre, three-parallel-group, double-blind, randomised controlled trial in participants undergoing different forms of IVF at seven centres in the UK and Hong Kong.
One group used TLI, another used standard static assessment with undisturbed culture, and a third employed conventional assessment with light microscopy. Results indicated no significant differences in live birth and clinical pregnancy rates among the groups.
TLI systems have been in use for many years and are usually more expensive than conventional methods. The results suggest that while they offer seamless monitoring, they do not enhance IVF outcomes. This is in line with several previous studies.
Overall, the research underscores the importance of evidence-based medicine in IVF treatment, challenging assumptions about the benefits of advanced technologies without proven clinical outcomes.