Matt Kaeberlein, Ph.D., is recognized globally as a leading scientist in the area of basic biology of aging. The premise of his research is that understanding the molecular mechanisms of aging will lead to interventions that slow the onset and progression of age-related chronic conditions, such as cancer, diabetes, kidney disease, heart disease, Alzheimer’s and others. Dr. Kaeberlein received his Ph.D. from the Massachusetts Institute of Technology in 2002 and performed his post-doctoral research in the Department of Genome Sciences at the University of Washington. Dr. Kaeberlein was appointed as an Assistant Professor of Pathology in 2006 and was promoted to Associate Professor in 2011. Dr. Kaeberlein has authored more than 140 publications in top scientific journals, including 19 published in Nature and Science, his work has also been featured in the popular press. Dr. Kaeberlein has been recognized with several awards, including a Breakthroughs in Gerontology Award from the Glenn Foundation, an Alzheimer’s Association Young Investigator Award, an Ellison Medical Foundation New Scholar in Aging Award, an Undergraduate Research Mentor of the Year Award, and a Murdock Trust Award. In 2011, he was named the Vincent Cristofalo Rising Star in Aging Research by the American Federation for Aging Research and appointed as a Fellow of the Gerontological Society of America, and in 2012 he joined the Board of Directors of the American Aging Association. Dr. Kaeberlein currently serves on the editorial boards for Science, Aging Cell, Cell Cycle, PloS One, Frontiers in Genetics of Aging, BMC Longevity and Healthspan, F1000 Research, Ageing Research Reviews, and BioEsssays. In addition to his primary appointment, Dr. Kaeberlein is the Director of the Dog Aging Project, co-Director of the University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging, the founding Director of the Healthy Aging and Longevity Research Institute, and the current President of the American Aging Association. Selected Publications: 1: Kaeberlein M, Rabinovitch PS, Martin GM. Healthy aging: The ultimate preventative medicine. Science. 2015 Dec 4;350(6265):1191-3. 2: Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M. Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science. 2015 Dec 11;350(6266):1375-8. 3: Bitto A, Wang AM, Bennett CF, Kaeberlein M. Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harb Perspect Med. 2015 Nov 2;5(11). pii: a025114. 4: McCormick MA, Delaney JR, Tsuchiya M, Tsuchiyama S, Shemorry A, Sim S, Chou AC, Ahmed U, Carr D, Murakami CJ, Schleit J, Sutphin GL, Wasko BM, Bennett CF, Wang AM, Olsen B, Beyer RP, Bammler TK, Prunkard D, Johnson SC, Pennypacker JK, An E, Anies A, Castanza AS, Choi E, Dang N, Enerio S, Fletcher M, Fox L, Goswami S, Higgins SA, Holmberg MA, Hu D, Hui J, Jelic M, Jeong KS, Johnston E, Kerr EO, Kim J, Kim D, Kirkland K, Klum S, Kotireddy S, Liao E, Lim M, Lin MS, Lo WC, Lockshon D, Miller HA, Moller RM, Muller B, Oakes J, Pak DN, Peng ZJ, Pham KM, Pollard TG, Pradeep P, Pruett D, Rai D, Robison B, Rodriguez AA, Ros B, Sage M, Singh MK, Smith ED, Snead K, Solanky A, Spector BL, Steffen KK, Tchao BN, Ting MK, Vander Wende H, Wang D, Welton KL, Westman EA, Brem RB, Liu XG, Suh Y, Zhou Z, Kaeberlein M, Kennedy BK. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. Cell Metab. 2015 Nov 3;22(5):895-906. 5: Wang AM, Promislow DE, Kaeberlein M. Fertile waters for aging research. Cell. 2015 Feb 26;160(5):814-5. 6: Bitto A, Kaeberlein M. Rejuvenation: it's in our blood. Cell Metab. 2014 Jul 1;20(1):2-4. 7: Bennett CF, Vander Wende H, Simko M, Klum S, Barfield S, Choi H, Pineda VV, Kaeberlein M. Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans. Nat Commun. 2014 Mar 24;5:3483. 8: Promislow DE, Kaeberlein M. Development. Chemical warfare in the battle of the sexes. Science. 2014 Jan 31;343(6170):491-2. 9: Johnson SC, Yanos ME, Kayser EB, Quintana A, Sangesland M, Castanza A, Uhde L, Hui J, Wall VZ, Gagnidze A, Oh K, Wasko BM, Ramos FJ, Palmiter RD, Rabinovitch PS, Morgan PG, Sedensky MM, Kaeberlein M. mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome. Science. 2013 Dec 20;342(6165):1524-8. 10: Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M. Preserving youth: does rapamycin deliver? Sci Transl Med. 2013 Nov 13;5(211):211fs40. 11: Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan 17;493(7432):338-45. 12: Ramos FJ, Chen SC, Garelick MG, Dai DF, Liao CY, Schreiber KH, MacKay VL, An EH, Strong R, Ladiges WC, Rabinovitch PS, Kaeberlein M, Kennedy BK. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci Transl Med. 2012 Jul 25;4(144):144ra103. 13: Ramos FJ, Kaeberlein M. Ageing: A healthy diet for stem cells. Nature. 2012 Jun 27;486(7404):477-8. 14: Leiser SF, Kaeberlein M. A role for SIRT1 in the hypoxic response. Mol Cell. 2010 Jun 25;38(6):779-80. 15: Kaeberlein M. Lessons on longevity from budding yeast. Nature. 2010 Mar 25;464(7288):513-9.Review. 16: Kaeberlein M. Spermidine surprise for a long life. Nat Cell Biol. 2009 Nov;11(11):1277-8. 17: Kaeberlein M, Kapahi P. Cell signaling. Aging is RSKy business. Science. 2009 Oct 2;326(5949):55-6. 18: Kaeberlein M, Kennedy BK. Ageing: A midlife longevity drug? Nature. 2009 Jul 16;460(7253):331-2. 19: Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science. 2009 May 29;324(5931):1196-8. 20: Kaeberlein M. Cell biology: A molecular age barrier. Nature. 2008 Aug 7;454(7205):709-10. 21: Kaeberlein M. The ongoing saga of sirtuins and aging. Cell Metab. 2008 Jul;8(1):4-5. 22: Steffen KK, MacKay VL, Kerr EO, Tsuchiya M, Hu D, Fox LA, Dang N, Johnston ED, Oakes JA, Tchao BN, Pak DN, Fields S, Kennedy BK, Kaeberlein M. Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell. 2008 Apr 18;133(2):292-302. 23: Kaeberlein M, Rabinovitch PS. Medicine: grapes versus gluttony. Nature. 2006 Nov 16;444(7117):280-1. 24: Kaeberlein M, Steffen KK, Hu D, Dang N, Kerr EO, Tsuchiya M, Fields S, Kennedy BK. Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction". Science. 2006 Jun 2;312(5778):1312; 25: Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science. 2005 Nov 18;310(5751):1193-6. 26: Kennedy BK, Smith ED, Kaeberlein M. The enigmatic role of Sir2 in aging. Cell. 2005 Nov 18;123(4):548-50.