Professor Dame Linda Partridge graduated from Oxford with a PhD degree. She works on the biology of ageing. Her research is directed to understanding both how the rate of ageing evolves in nature and the mechanisms by which healthy lifespan can be extended in laboratory model organisms. Her work has focused in particular on the role of nutrient-sensing pathways, such as the insulin/insulin-like growth factor signalling pathway, and on dietary restriction. Her current work is directed to developing pharmacological treatments that ameliorate the human ageing process to produce a broad-spectrum improvement in health during ageing. She is the recipient of numerous awards, including giving the Royal Society Croonian Lecture in 2009 and a DBE for Services to Science. She is a Fellow of the Royal Society, the Academy of Medical Sciences, the European Academy of Sciences and the American Academy of Arts and Sciences. She is the Director of the UCL Institute of Healthy Ageing, as well as founding director of the Max Planck Institute for Biology of Ageing in Cologne. Prof Partridge has published over 380 papers and has made significant contribution to the aging research especially in signaling pathways controlling aging processes. Selected Publications: 1. Soultoukis GA, Partridge L. Dietary Protein, Metabolism, and Aging. Annu Rev Biochem. 2016 Jun 2;85:5-34. 2. Castillo-Quan JI, Li L, Kinghorn KJ, Ivanov DK, Tain LS, Slack C, Kerr F, Nespital T, Thornton J, Hardy J, Bjedov I, Partridge L. Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Rep. 2016 Apr 19;15(3):638-50. 3. Regan JC, Khericha M, Dobson AJ, Bolukbasi E, Rattanavirotkul N, Partridge L. Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction Elife. 2016 Feb 16;5:e10956. 4. Slack C, Alic N, Foley A, Cabecinha M, Hoddinott MP, Partridge L. The Ras-Erk-ETS-Signaling Pathway Is a Drug Target for Longevity. Cell. 2015 Jul 2;162(1):72-83. 5. Fontana L, Partridge L. Promoting health and longevity through diet: from model organisms to humans. Cell. 2015 Mar 26;161(1):106-18. Review. 6. Alic N, Tullet JM, Niccoli T, Broughton S, Hoddinott MP, Slack C, Gems D, Partridge L. Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Rep. 2014 Feb 27;6(4):608-16. 7. Piper MD, Blanc E, Leitão-Gonçalves R, Yang M, He X, Linford NJ, Hoddinott MP, Hopfen C, Soultoukis GA, Niemeyer C, Kerr F, Pletcher SD, Ribeiro C, Partridge L. A holidic medium for Drosophila melanogaster. Nat Methods. 2014 Jan;11(1):100-5. 8. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. 9. Partridge L. Diet and healthy aging. N Engl J Med. 2012 Dec 27;367(26):2550-1. 10. Gems D, Partridge L. Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol. 2013;75:621-44. Review. 11. Alic N, Partridge L. Death and dessert: nutrient signalling pathways and ageing. Curr Opin Cell Biol. 2011 Dec;23(6):738-43. Review. 12. Bjedov I, Toivonen JM, Kerr F, Slack C, Jacobson J, Foley A, Partridge L. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 2010 Jan;11(1):35-46. 13. Grandison RC, Piper MD, Partridge L. Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature. 2009 Dec 24;462(7276):1061-4. 14. Toivonen JM, Gems D, Partridge L. Longevity of Indy mutant Drosophila not attributable to Indy mutation. Proc Natl Acad Sci U S A. 2009 May 26;106(21):E53; 15. Murphy MP, Partridge L. Toward a control theory analysis of aging. Annu Rev Biochem. 2008;77:777-98. Review. 16. Gems D, Partridge L. Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab. 2008 Mar;7(3):200-3. Review. 17. Wong R, Piper MD, Blanc E, Partridge L. Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster. Nat Methods. 2008 Mar;5(3):214-5; 18. Pletcher SD, Kabil H, Partridge L. Chemical Complexity and the Genetics of Aging. Annu Rev Ecol Evol Syst. 2007 Dec 1;38:299-326. 19. Partridge L, Gems D. Benchmarks for ageing studies. Nature. 2007 Nov 8;450(7167):165-7. 20. Partridge L, Gems D, Withers DJ. Sex and death: what is the connection? Cell. 2005 Feb 25;120(4):461-72. Review. 21. Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 2004 Aug;14(8):408-12. Review. 22. Giannakou ME, Goss M, Jünger MA, Hafen E, Leevers SJ, Partridge L. Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science. 2004 Jul 16;305(5682):361. 23. Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science. 2003 Sep 19;301(5640):1731-3. 24. Partridge L, Gems D. A lethal side-effect. Nature. 2002 Aug 29;418(6901):921. 25. Partridge L, Gems D. Mechanisms of ageing: public or private Nat Rev Genet. 2002 Mar;3(3):165-75. Review. 26. Clancy DJ, Gems D, Hafen E, Leevers SJ, Partridge L. Dietary restriction in long-lived dwarf flies. Science. 2002 Apr 12;296(5566):319.